Myrtle will return to action on the gridiron on Friday after an open date and will host the powerful Biggersville Lions in the Division 1-1A opener for both schools.
Myrtle is 0-2 on the season with losses to Marshall Academy (14-0) and Walnut (39-13).
Biggersville comes into the contest at 3-0 with wins over TCPS (46-21), Hatley (60-6) and Smithville (64-0).
Biggersville won the 2019 meeting between the schools by a 46-20 score.
Kickoff will be at 7:00.